The Yangtze River, the third largest river and supporting nearly one-third of Chinese population, has been severely polluted in recent decades. Among the numerous pollutants, organic micropollutants, as one kind of important emerging contaminants, are currently key contaminants of concern. However, few studies have focused on their mixture environmental impacts, especially for the complex environmental mixtures. In the current study, four categories of organic micropollutants, including 16 polycyclic aromatic hydrocarbons (PAHs), 32 polychlorinated biphenyls (PCBs), 27 organochlorine pesticides (OCPs) and 20 pharmaceutical and personal care products (PPCPs) are analyzed in 10 study sites on the Yangtze River. Subsequently, comprehensive risk assessment for micropollutant mixtures was conducted by risk quotient based on the sum of PEC/PNEC values (RQ(MEC/PNEC)) and risk quotient based on the toxic units (RQ(STU)). The mixture risk evaluation based on the detected environmental concentrations indicates that micropollutant mixtures in surface water of the Yangtze River exhibited relative high risks for aquatic organisms. The observed results revealed that mixture risk assessments have to consider the complexity of environmental samples; PCBs dominated main mixture risks in the upper stream; PAHs contributed major comprehensive risks in the middle stream; and OCPs were the key micropollutants in the downstream. The outcomes of the present study here can serve for pollution control in the Yangtze River, which provide the scientific underpinnings and regulatory reference for risk management and river protection.

(来源：SCIENCE OF THE TOTAL ENVIRONMENT 卷：780 出版年：2021 DOI: 10.1016/j.scitotenv.2021.146537)