作者: Gao, Shixiong; Liu, Hang; Chang, Hong; 等. 

A variety of anthropogenic chemicals can disrupt the equilibrium of intrinsic biological metabolites in organisms, leading to metabolic disorders and an increased risk of metabolic syndromes. However, exposure to pollutants that induce metabolic disorders in wildlife as a cause of adverse effects is unknown. In this study, approximately 3108 compounds, including 11 groups of metabolites and 388 pollutants, were simultaneously identified in the blood of wild crucian carp (Carassius auratus) captured in three bays of Taihu Lake, China. A visualized network linking thousands of co-regulated metabolites was automatically produced for the screened signals. This comprehensive view of the differences in blood metabolite profiles in carp from the north and south bays showed that triglycerides (TGs) were the intrinsic molecules most affected by differing environmental pollution in each bay. The regional differences in metabolite profiles were linked to exposure to screened perfluorinated compounds that displayed corresponding regional differences in concentrations and effects on TGs in in vivo exposure tests. Perfluoroundecanoic acid (PFUnDA) was the key pollutant responsible for the variation in blood TGs in wild crucian carp, and exposure to PFUnDA resulted in extremely high biological activity on lipid deposition in the liver tissues of crucian carp at environmental levels.

Environmental science & technology   卷: 54   期: 6   页: 3343-3352   出版年: 2020